Index Catalog // Arch : Northwestern University Institutional Repository

Description:: Chromatin is the biological material that packages our genetic information. In humans, 2 meters of linear DNA is compacted into an approximately 6 μm nucleus. Our DNA is transcribed into RNA, which is then translated into proteins. Cellular phenotype, the composite of all cellular functions, is defined by the entire...
Keyword:: Computational Modeling, Genomics, Chromatin, Nanoimaging, and Biophysics
Subject:: Biomedical engineering
Creator:: Virk, Ranya Kaur Aphrodite
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 09/22/2022
Date Created:: 2022-01-01
Resource Type:: Dissertation
Alternate Identifier:: http://dissertations.umi.com/northwestern:16197 and etdadmin_upload_924911

Description:: Type I interferon (IFN) is the primary antiviral cytokine establishing a broad and potent antiviral response to protect mammalian cells from virus infection. The functional repertoire of IFN extends to innate and adaptive immunity, neoplastic transformation, resistance and cancer immunotherapy. IFN functions are primarily mediated through the Janus kinase (JAK)...
Keyword:: ISGF3, Interferon, Chromatin, Antiviral, ISG, and H2A.Z
Subject:: Virology, Molecular biology, and Cellular biology
Creator:: Au Yeung, Weng Si (Nancy)
Owner:: Scholarly Digital Publishing
Language:: en
Date Uploaded:: 02/12/2020
Date Created:: 2018-01-01
Resource Type:: Dissertation
Alternate Identifier:: etdadmin_upload_618020 and http://dissertations.umi.com/northwestern:14409

Description:: Chromatin organization involves a hierarchy of length scales ranging from a few tens of nanometers in nucleosomes to hundreds of nanometers for chromosomal territories. This physical nanostructure is regulated by the genetic code, differential methylation and histone modifications that comprise the histone code, as well as non-molecular factors, such as...
Keyword:: Physicochemical, Nanoscale, Chromatin, and Transcription
Subject:: Interdepartmental Biological Sciences (IBiS) Graduate Program
Creator:: Greta Mary Wodarcyk
Owner:: Scholarly Digital Publishing
Date Uploaded:: 10/14/2019
Date Modified:: 10/14/2019
Resource Type:: Dissertation

Description:: Packaging of DNA into nucleosomes and chromatin not only enables DNA to fit within the nucleus, but it also protects and organizes DNA. However, the wrapping of DNA around histones occludes DNA from binding proteins in solution. Proteins that regulate, express and repair DNA are able to function only when...
Keyword:: Unwrapping, FRET, Mapping, Nucleosome, Chromatin, and Remodeling
Subject:: Interdepartmental Biological Sciences Program
Creator:: Hannah S. Tims
Owner:: Scholarly Digital Publishing
Date Uploaded:: 08/14/2018
Date Modified:: 08/14/2018
Date Created:: 2007-08-28
Resource Type:: Dissertation

Description:: The hormone prolactin (PRL) contributes to breast cancer pathogenesis through various signaling pathways, one of the most notable being the JAK2/signal transducer and activator of transcription 5 (STAT5) pathway. PRL-induced activation of the transcription factor STAT5 results in the upregulation of numerous genes implicated in breast cancer pathogenesis. However, the...
Keyword:: Transcription factor, HMGN, Histone H1, Chromatin, STAT5, and Prolactin
Subject:: Driskill Graduate Training Program in Life Sciences
Creator:: Suzanne Marie Schauwecker
Owner:: Scholarly Digital Publishing
Date Uploaded:: 04/18/2018
Date Modified:: 04/18/2018
Date Created:: 2017-01-01
Resource Type:: Dissertation

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