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Work[remove]23

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Dissertation17
Report2
Other1
Poster1

Creator

Andrea Calvert1
Brooke Michele Emerling1
David W. Prine 1
De Jesus, Adam1
Elizabeth Yvette Truesdell1
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Keyword

Inflammation2
Acoustic emission testing1
Anarchism1
Andes1
Atherosclerosis1
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Subject

Chemistry3
Integrated Graduate Program in the Life Sciences3
Biology2
Cellular biology2
Driskill Graduate Training Program in Life Sciences2
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en8
English2

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Northwestern University Libraries 2

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Infrastructure Technology Institute Publications2
Critical Theory in the Global South1
Northwestern University Transportation Center Collection1
Undergraduate Research and Arts Expo1

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Temas en Cultura 1

Keyword:

Critical Theory, Marxism, Anarchism, and Andes

Creator:

Víctor Vich

Owner:

Aerith Yorshka Netzer

Date Uploaded:

09/29/2023

Date Modified:

09/29/2023

Resource Type:

Other
Signaling Pathways Regulating HIF-1

Description:

Hypoxia is a reduction in the normal level of oxygen tension and occurs during acute and chronic vascular disease, pulmonary disease, and cancer. The key transcription factor that regulates the cellular responses to hypoxia is hypoxia-inducible-factor-1 (HIF-1). Understanding how HIF-1 is regulated is fundamental for understanding the biology of tumor...

Keyword:

Biology

Subject:

Interdepartmental Biological Sciences Program

Creator:

Brooke Michele Emerling

Owner:

Scholarly Digital Publishing

Date Uploaded:

06/25/2018

Date Modified:

06/25/2018

Date Created:

2007-05-14

Resource Type:

Dissertation
Role of Plasminogen Activator Inhibitor-1 (PAI-1) in Endothelial Senescence and Cardiovascular Aging

Description:

Plasminogen activator inhibitor-1 (PAI-1) is an essential mediator of senescence and a potential therapeutic target for preventing aging-related pathologies. Cellular Senescence is associated with organismal aging and related pathologies. In our study, we investigate the efficacies of PAI-1 inhibitors in both in vitro and in vivo models of homocysteine...

Keyword:

pai-1

Subject:

Biology

Creator:

Sun, Tianjiao

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Modified:

02/01/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15417 and etdadmin_upload_780977
Redox Homeostasis In the Skin: Peroxiredoxin 1 Promotes the Stability of a Pro-Differentiation Cadherin Desmoglein 1

Description:

Desmosomes, complex structures found at intercellular junctions, are important for the development, structural integrity, and immune barrier of the skin. Extracellular components of the desmosome connect neighboring cells and intracellular interactions amongst cadherin, armadillo, and plakin proteins anchor the desmosome to intermediate filaments. Beyond their canonical role as “spot welds”...

Subject:

Health sciences and Cellular biology

Creator:

Lee, Sherry

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

04/28/2020

Date Created:

2018-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_572406 and http://dissertations.umi.com/northwestern:14076
HEXOKINASE 1 SUBCELLULAR LOCALIZATION REGULATES THE METABOLIC FATE OF GLUCOSE

Description:

The product of hexokinase (HK) enzymes, glucose-6-phosphate, can be metabolized through glycolysis or directed to alternative pathways, such as the pentose phosphate pathway (PPP) to generate anabolic intermediates. HK1 contains an N-terminal domain that permits mitochondrial binding, but its physiologic significance remains unclear. We generated mice lacking the HK1 mitochondrial-binding...

Keyword:

Inflammation, Hexokinase, Macrophage, Subcellular localization, Metabolism, and Mitochondria

Subject:

Biology

Creator:

De Jesus, Adam

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/01/2021

Date Created:

2019-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_773389 and http://dissertations.umi.com/northwestern:15348
Effect of Group 1 CD1-restricted T cells on Atherosclerosis

Description:

Approximately 1 in 3 deaths in the US is caused by cardiovascular diseases, among them atherosclerosis. Atherosclerosis occurs through excessive cholesterol deposition (hyperlipidemia) along the inner layer of the artery called the intima, resulting in plaque formation that blocks arterial blood flow and could lead to heart attacks and strokes....

Keyword:

Atherosclerosis, LDLrko, Group 1 CD1-restricted T cells, CD1d, and HJ1-T cells

Subject:

Biological Sciences

Creator:

Shon Thomas

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/20/2018

Date Modified:

04/20/2018

Date Created:

2017-05-31

Resource Type:

Poster
Commercialization of NUCu Steel (TEA-21 Years 1-3 Final Report)

Description:

Northwestern University developed copper-precipitation-hardened, high-performance weathering steel (NUCu 70W Steel) that is produced by hot rolling after casting and then air-cooling. Due to simple processing the steel is fabricated at lower cost than competing high-performance steels that require quench and tempering. NUCu 70W steel can be easily welded without pre-...

Keyword:

NUCu steel

Creator:

Morris E. Fine and Semyon Vaynman

Owner:

Nurganym Agzamova

Publisher:

Northwestern University Libraries

Language:

English

Date Uploaded:

07/12/2017

Date Modified:

08/14/2017

Date Created:

2004

Resource Type:

Report
LY6K Promotes Glioblastoma Tumorigenicity via CAV-1-Mediated ERK1/2 Signaling Enhancement

Description:

Background: Glioblastoma (GBM) tumors are the most malignant brain cancers and are characterized as Grade IV astrocytomas by the World Health Organization. GBM tumors can be classified into three molecular subtypes known as proneural, classical, and mesenchymal. In addition, GBM tumors also have a small population of cells known as...

Keyword:

LY6K, Methylation, Glioblastoma, ERK1/2, and CAV-1

Subject:

Molecular biology, Oncology, and Neurosciences

Creator:

Sastry, Namratha G

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

01/21/2021

Date Created:

2020-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_733180 and http://dissertations.umi.com/northwestern:15049
Inhibitors of the Ubiquitin Ligase Nedd4-1 Discovered by Covalent Fragment Screening

Description:

The FDA approvals of afatinib and ibrutinib in 2013 led to a heightened interest in cysteine-reactive covalent inhibitors. However, there are few methods to discover new cysteine-reactive inhibitors for enzymes for which reversible binding scaffolds are not known. To this end, we rationally designed a chemical system to attach a...

Keyword:

Electrophile, Covalent, Fragment, Ubiquitin, and Nedd4-1

Subject:

Chemistry

Creator:

Stefan Kathman

Owner:

Scholarly Digital Publishing

Date Uploaded:

02/19/2018

Date Modified:

02/19/2018

Date Created:

2016-01-01

Resource Type:

Dissertation
Transport jet aircraft noise abatement in foreign countries : growth, structure, impact: Volume 1

Keyword:

Northwestern University Transportation Center

Creator:

Frank A. Spencer

Owner:

Institutional Repository Administrator

Date Uploaded:

05/04/2022

Date Modified:

05/04/2022

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