This dissertation demonstrates how related initiatives to reform narcotics laws and protect consumers from dangerous medicines – taking hold in the 1950s and institutionalized in the mid-1960s – created the foundation for a massive expansion of federal policing of illicit drugs. Centered on the history of the Food and Drug...
Understanding the chemical complexity of the extracellular matrix (ECM) and how chemical, biological, and physical cues bring changes to the behavior of cells has remained a grand challenge. Addressing these questions requires not only achieving systematic control over the interactions between cells and the ECM but also utilizing suitable analytical...
Introduction: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction associated with reduced quality of life, increased rates of depression and anxiety, and high economic burden to society and the individual. Current behavioral interventions, which target well-known symptom exacerbating factors such as catastrophizing and gastrointestinal- specific anxiety, have demonstrated...
Background: Evidence supporting a bidirectional relationship between depression and recurrent cardiovascular disease (CVD) appears strong, but there remains a need to better characterize the role of depression in CVD risk and cardiovascular health (CVH) promotion, especially in the context of comorbid risk factors such as cigarette smoking. In the present...
From 2008 to 2019, a range of new interactive and immersive digital formats that present new possibilities for musical and artistic expression have become available. In order to begin the work of uncovering what new compositional and experiential possibilities are now possible, this document will examine each format’s core concepts...
Objective: To evaluate patient-reported experiences of telehealth and disparities in access, use, and satisfaction with telehealth visits during the COVID-19 pandemic (aim 1), to evaluate prevalence of portal use pre-, peri-, and post-pandemic, among the C3 cohort, and investigate any disparities in use by sociodemographic factors (aim 2), and to...
Phonotactic patterns are generalizations that govern the order of consonants and vowels, within words and syllables. Certain second-order phonotactic patterns—those that relate multiple sounds within a syllable, such as “if the vowel is [ɪ], then [s] can only appear at the end of the syllable”—require a period of sleep-based consolidation...
The predominant, categorical system used to classify and diagnose psychiatric disorders suffers from several critical scientific limitations, including extensive comorbidity, unreliability, and disorder heterogeneity. As such, clinical psychological scientists are increasingly moving away from this traditional, categorical system, and toward empirically-based, dimensional, and transdiagnostic alternatives such as the Hierarchical Taxonomy...
In a wide range of political systems, political parties and politicians deliver special favors and material benefits to their constituents as a means of mobilizing their support during elections. This phenomenon, called patronage politics, is the focus of this dissertation. Although existing research has uncovered important variations in the patterns...
Genetic studies have found variants in the protein-degrading autophagy-lysosomal pathway (ALP) to be among the most common risk factors for developing Parkinson’s disease (PD). Macroautophagy (MA) is the arm of this pathway which delivers cytosolic components to lysosomes for degradation and is essential for neuronal health. The defining pathological protein...