Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that weak repressors of gene expression provide the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that...
Advances in biosensor engineering have enabled the design of programmable molecular systems to detect a range of pathogens, nucleic acids, and chemicals. Here, we engineer and field-test a biosensor for fluoride, a major groundwater contaminant of global concern. The sensor consists of a cell-free system containing a DNA template that...
In May 2018, the US Food and Drug Administration approved daily oral pre-exposure prophylaxis (PrEP) for adolescents under age 18. Although this is an important step toward HIV prevention for adolescents assigned male at birth who have sex with males (AMSM), limited research exists to gauge their awareness of PrEP...
Importance: Despite its efficacy, low tidal volume ventilation (LTVV) remains severely underutilized for patients with acute respiratory distress syndrome (ARDS). Physician under-recognition of ARDS is a significant barrier to LTVV use. We propose a computational method that addresses some of the limitations of the current approaches to automated measurement of...
ARTICLE 3: TITLE. A phase-shifting anterior-posterior network organizes global phase relations. ABSTRACT. Prior research has identified a variety of task-dependent networks that form through inter-regional phase-locking of oscillatory activity that are neural correlates of specific behaviors. Despite ample knowledge of task-specific functional networks, general rules governing global phase relations have..., ARTICLE 1: TITLE. Probabilistic, entropy-maximizing control of large-scale neural synchronization.
ABSTRACT. Oscillatory neural activity is dynamically controlled to coordinate perceptual, attentional and cognitive processes. On the macroscopic scale, this control is reflected in the U-shaped deviations of EEG spectral-power dynamics from stochastic dynamics, characterized by disproportionately elevated occurrences of the..., and ARTICLE 2: TITLE. Spatiotemporal dynamics of maximal and minimal EEG spectral power.
ABSTRACT. Oscillatory neural activities are prevalent in the brain with their phase realignment contributing to the coordination of neural communication. Phase realignments may have especially strong (or weak) impact when neural activities are strongly synchronized (or desynchronized) within...
Readme for Federal Circuit data file created by Melissa F. Wasserman and Jonathan D. Slack. The data file contains Federal Circuit opinions in each row and case/opinion attributes on the columns. The data file covers opinions issued from 10.13.2004 through 1.30.2018. This data file is the basis for the article...
Spatiotemporal dynamics of EEG/MEG (electro-/magneto-encephalogram) have typically been investigated by applying time-frequency decomposition and examining amplitude-amplitude, phase-phase, or phase-amplitude associations between combinations of frequency bands and scalp sites, primarily to identify neural correlates of behaviors and traits. Instead, we directly extracted global EEG spatiotemporal dynamics as trajectories of k-dimensional state...
There is growing evidence that growth with invasive species influences the traits of co-occurring native plants over multiple generations. Some studies indicate that these experienced populations perform better in the presence of the invasive species that led to the trait changes. These experienced populations could serve as source material for...
Soil texture has important ramifications on the shape and size of roots as well as impacting how much water is taken up and the distribution of nutrients in the soil. These factors lead to differences in growth characteristics and plant performance. However, what traits and how the plant responds to...
Understanding how root traits vary within a species and how traits respond to heterogeneous environments, can provide important insight into functional plant attributes that influence plant survival in competitive environments. Selecting plant material with root traits that will support its survival in heterogenous environments may help improve the outcomes of...