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Developing Immunotherapy Targeting Immune Suppression Using Spherical Nucleic Acids (SNAs)

Description:

Cancer remains a leading cause of death worldwide, necessitating continued study to explore and unravel its complex etiology. For example, there has been a shift of focus in cancer treatment from surgery and radiotherapy to targeted chemo- and immunotherapies as we gain more knowledge on the hallmarks of cancer (e.g.,...

Keyword:

tumor microenvironment, nanomedicine, Checkpoint inhibitor, spherical nucleic acids, gene expression/knockdown, and immunotherapy

Subject:

Nanotechnology, Oncology, and Immunology

Creator:

Chou, Liyushang

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/16/2023

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_884998 and http://dissertations.umi.com/northwestern:15965
Mapping out the pathways for spherical nucleic acid biodistribution

Description:

Oligonucleotides can be used to modulate the regulation of pathological genes that are associated with various diseases. However, due to biological barriers, efficient delivery of oligonucleotides, especially to extrahepatic tissues, remains a challenge. To overcome these barriers, multiple delivery strategies have been developed, ranging from medicinal chemistry to nanotechnology. Nanoparticle-based...

Keyword:

surface modification, biodistribution, and spherical nucleic acids

Subject:

Chemistry

Creator:

Zhang, Wuliang

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_830130 and http://dissertations.umi.com/northwestern:15627

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Developing Immunotherapy Targeting Immune Suppression Using Spherical Nucleic Acids (SNAs)

Mapping out the pathways for spherical nucleic acid biodistribution

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