Herpesviruses require axonal transport for the successful establishment of infection in peripheral ganglia (retrograde transport), and the subsequent spread to exposed body surfaces following reactivation from latency (anterograde transport). Viral progeny are assembled and spread to other tissues or hosts during egress. I focused on viral proteins which modulate directed...
The neurotropic alphaherpesviruses infect and spread trans-synaptically within the vertebrate nervous system. Recurrent diseases are often manifested at the periphery of the host organism but occasional dissemination of the virus to the brain results in fatal encephalitis. Interactions between viral and host cellular proteins are integral to the success of...