One of the fundamental observations in oncology is that the rate of cancer malignancy increases with age, which applies to most human malignancies including breast cancer. Therefore, it is crucial to elucidate the mechanistic connection between aging and carcinogenesis. The NAD+-dependent sirtuin family, specifically SIRT3, the primary mitochondrial deacetylase, which...
Glioblastoma (GBM) is a highly malignant brain tumor that accounts for the most commonly diagnosed type of primary brain tumors in adults. It has a poor prognosis of only 15 months from the time of diagnosis. The gold standard therapy regimen consists of radiotherapy and the chemotherapeutic temozolomide. Both of...