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Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Description:

Biological therapeutics have revolutionized the way we treat cancer due to their ability to target tumors discriminately, leaving healthy cells unaffected. However, our inability to tailor the structure of biologics may hamper their optimization for efficacy. This lack of programmability contributes to factors such as immunogenic responses, inability to penetrate...

Keyword:

Nanotechnology, Cancer therapy, Synthetic biology, Synthetic chemistry, Protein engineering, and Protein scaffolds

Subject:

Bioengineering, Chemistry, and Chemical engineering

Creator:

Kimmel, Blaise Russel

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

02/02/2022

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_852716 and http://dissertations.umi.com/northwestern:15804
Development of a Generalizable Strategy for Converting Metabolite Binding Proteins into Metabolite Responsive Transcription Factors

Description:

Metabolite biosensors are powerful tools for basic biological research, medical diagnostics, and biotechnological applications. However, a generalizable strategy for developing new metabolite biosensors when an existing sensor cannot be found in nature, is a persistent challenge. Furthermore, while transcription factor biosensors have the broadest range of applications, the pool of...

Keyword:

Bioengineering, Transcription factor, Synthetic biology, Promoter engineering, Protein engineering, and Metabolic engineering

Subject:

Interdepartmental Biological Sciences (IBiS) Graduate Program

Creator:

Andrew Younger

Owner:

Scholarly Digital Publishing

Date Uploaded:

04/18/2018

Date Modified:

04/18/2018

Date Created:

2017-01-01

Resource Type:

Dissertation

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Engineering Protein Scaffolds as Programmable Cancer Therapeutics

Development of a Generalizable Strategy for Converting Metabolite Binding Proteins into Metabolite Responsive Transcription Factors

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