Transcription plays a pivotal role in the transfer of genetic information within living organisms. It serves as the initial step in gene expression, allowing cells to convert the instructions encoded in their DNA into functional molecules. Eukaryotic transcription initiation is a complex and dynamic process that requires joint efforts from...
Packaging of DNA into nucleosomes and chromatin not only enables DNA to fit within the nucleus, but it also protects and organizes DNA. However, the wrapping of DNA around histones occludes DNA from binding proteins in solution. Proteins that regulate, express and repair DNA are able to function only when...