Northwestern University

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Filtering by: Creator Marinaccio, Christian Resource type Dissertation Subject Medicine

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Myeloproliferative Neoplasms: From Biology to Targeted Therapeutics

Description:

The BCR-ABL negative Myeloproliferative Neoplasms (MPNs) are clonal hematopoietic stem-cell disorders characterized by abnormal proliferation of differentiated myeloid lineages. MPNs include 3 clinically distinct disorders: Polycythemia Vera (PV), Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF). 95% of MPNs are characterized by driver mutations in Janus Kinase 2 (JAK2), Thrombopoietin receptor...

Keyword:

STK11, AML, Megakaryocytes, Reactive Oxygen Species, Leukemia, and MPN

Subject:

Biology and Medicine

Creator:

Marinaccio, Christian

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

04/15/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

http://dissertations.umi.com/northwestern:15470 and etdadmin_upload_796403