Northwestern University

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Filtering by: Creator Grigoryeva, Lubov Sergeevna Subject Microbiology Subject Molecular biology

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Human macrophages utilize a wide range of pathogen recognition receptors to respond to Legionella pneumophila

Description:

Cytokines made by macrophages play a critical role in determining the course of Legionella pneumophila infection. Prior, murine-based modeling indicated that the cytokine response initiated upon recognition of L. pneumophila involves a subset of Toll-like receptors, namely TLR2, TLR5, and TLR9. Using shRNA/siRNA knockdowns and subsequently CRISPR/Cas9 knockouts (KO), I...

Keyword:

TLR4, Legionella pneumophila, Macrophage , Toll-like Receptors, and TLR3

Subject:

Microbiology, Molecular biology, and Immunology

Creator:

Grigoryeva, Lubov Sergeevna

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

10/07/2021

Date Created:

2021-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_839521 and http://dissertations.umi.com/northwestern:15684