Northwestern University

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Filtering by: Creator Chen, Siyu Subject Biophysics

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Structural Visualization of State Transition during Non-Homologous End-Joining (NHEJ)

Description:

DNA double-strand breaks (DSBs) are caused by either endogenous agents or exogenous ionizing radiation and chemicals. Incorrect DSB repair can lead to undesired genome rearrangements. Homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways are two major DNA repair pathways that repair DSBs and maintain genome integrity. When homologous DNA is...

Keyword:

DNA repair, Cryo EM, NHEJ, DNA-PKcs, Cancer, and CRISPR

Subject:

Molecular biology, Biochemistry, and Biophysics

Creator:

Chen, Siyu

Owner:

Scholarly Digital Publishing

Language:

en

Date Uploaded:

06/22/2022

Date Created:

2022-01-01

Resource Type:

Dissertation

Alternate Identifier:

etdadmin_upload_879511 and http://dissertations.umi.com/northwestern:15936